Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9.4 Tesla.

Moritz ZaissAnnasofia AnemoneSteffen GoerkeDario Livio LongoKai HerzRolf PohmannSilvio AimeMichal RivlinGil NavonXavier GolayKlaus Scheffler

Published in: NMR in biomedicine (2019)

For the determined fast exchange regime, presaturation pulses in the spin-lock regime (long recover time, short yet strong saturation) were found to be optimal. This study gives an estimation for optimization of the glucoCEST signal in vivo on the basis of glucose exchange rate at physiological conditions.

Keyphrases

blood glucose
magnetic resonance
magnetic resonance imaging
contrast enhanced
type diabetes
room temperature
computed tomography
density functional theory
adipose tissue
blood pressure
skeletal muscle
insulin resistance