Simultaneous nanostructure and chemical imaging of intact whole nematodes.

Michael W M JonesNicholas W PhillipsBrian AbbeyDominic James HareGrant A van RiessenDavid J VineMartin D de Jonge Gawain McColl

Published in: Chemical communications (Cambridge, England) (2019)

Biological X-ray fluorescence microscopy (XFM) is an important tool for determining quantitative distributions of bioinorganics and essential trace elements. Here we present a new analysis approach for rapid nanoscale ptychographic imaging and simultaneous chemical mapping of large radiation sensitive specimens without image degradation associated with probe evolution.

Keyphrases

high resolution
single molecule
mass spectrometry
high speed
deep learning
optical coherence tomography
living cells
machine learning
radiation induced
photodynamic therapy
single cell
loop mediated isothermal amplification