Longitudinal Virological and Immunological Profile in a Case of Human Monkeypox Infection.

Maria Antonella ZingaropoliAlberico ParenteBlerta KertushaRoberta CampagnaTiziana TieghiSilvia GarattiniRaffaella MaroccoAnna CarraroEeva TortelliniMariasilvia GuardianiFederica DominelliOmbretta TurrizianiMaria Rosa CiardiClaudio Maria MastroianniCosmo Del BorgoMiriam Lichtner

Published in: Open forum infectious diseases (2022)

In a male with severe proctitis, monkeypox virus DNA was detected in skin lesions, blood, the nasopharynx, and the rectum, underlying generalized viral spreading. Rectal involvement was still found when skin lesions disappeared. At this early stage, an increase of cytotoxic and activated T cells was observed, while a reduction in CD56dimCD57+ NK cells compared with recovery time point was observed.

Keyphrases

nk cells
early stage
soft tissue
endothelial cells
wound healing
sars cov
circulating tumor
hiv infected
single molecule
rectal cancer
early onset
antiretroviral therapy
drug induced
nucleic acid
neoadjuvant chemotherapy