Identification of key genes and functions of circulating tumor cells in multiple cancers through bioinformatic analysis.

Yibing GuanFangshi XuYiyuan WangJuanhua TianZiyan WanZhenlong WangTie Chong

Published in: BMC medical genomics (2020)

In summary, our study suggests that compared with primary tumors, CTCs mainly change cell adhesion, EMT, and apoptosis. PSMC2 can be used as a poor prognostic factor.

Keyphrases

circulating tumor cells
prognostic factors
cell adhesion
bioinformatics analysis
circulating tumor
epithelial mesenchymal transition
oxidative stress
endoplasmic reticulum stress
genome wide
cell death
cell cycle arrest
gene expression
dna methylation
signaling pathway
transcription factor