Gut microbiota depletion by antibiotics ameliorates somatic neuropathic pain induced by nerve injury, chemotherapy, and diabetes in mice.

Pingchuan MaRufan MoHuabao LiaoChengjie QiuGenhao WuCaixia YangYunxiao ZhangYiran ZhaoXue-Jun Song

Published in: Journal of neuroinflammation (2022)

This study demonstrates distinct roles of gut microbiota in the pathogenesis of chronic painful conditions with nerve injury, chemotherapy and diabetic neuropathy and supports the clinical significance of fecal bacteria transplantation.

Keyphrases

neuropathic pain
type diabetes
spinal cord
spinal cord injury
locally advanced
cardiovascular disease
peripheral nerve
glycemic control
mouse model
stem cells
high fat diet induced
copy number
gene expression
dna methylation
insulin resistance
adipose tissue
drug induced