NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.

Sen YangZhen-Xian NiouAndrea EnriquezJacob LaMarJui-Yen HuangKaren LingPaymaan Jafar-NejadJonathan GilleyMichael P ColemanJason M TennessenVidhya RangarajuHui-Chen Lu

Published in: Molecular neurodegeneration (2024)

NMNAT2 ensures axonal health by maintaining NAD redox potential in distal axons to ensure efficient vesicular glycolysis required for fast axonal transport.

Keyphrases

spinal cord injury
optic nerve
healthcare
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