Biogenic Copper Selenide Nanoparticles for Near-Infrared Photothermal Therapy Application.
Xue-Meng WangShaoshan PanLin ChenLi WangYi-Tao DaiTianzhi LuoWen-Wei LiPublished in: ACS applied materials & interfaces (2023)
Near-infrared (NIR) photothermal therapy (PTT) is attractive for cancer treatment but is currently restricted by limited availability and insufficient NIR-II photoactivity of photothermal agents, for which artificial nanomaterials are usually used. Here, we report the first use of biogenic nanomaterials for PTT application. A fine-controlled extracellular biosynthesis of copper selenide nanoparticles (bio-Cu 2- x Se) by Shewanella oneidensis MR-1 was realized. The resulting bio-Cu 2- x Se, with fine sizes (∼35.5 nm) and high product purity, exhibited 76.9% photothermal conversion efficiency under 1064 nm laser irradiation, outperforming almost all the existing counterparts. The protein capping also imparted good biocompatibility to bio-Cu 2- x Se to favor a safe PTT application. The in vivo PTT with injected bio-Cu 2- x Se in mice (without extraction nor further modification) showed 87% tumor ablation without impairing the normal organisms. Our work not only opens a green route to synthesize the NIR-II photothermal nanomaterial but may also lay a basis for the development of bacteria-nanomaterial hybrid therapy technologies.
Keyphrases
- photodynamic therapy
- drug release
- fluorescence imaging
- aqueous solution
- air pollution
- cancer therapy
- drug delivery
- metal organic framework
- magnetic resonance
- stem cells
- magnetic resonance imaging
- fluorescent probe
- adipose tissue
- atrial fibrillation
- high fat diet induced
- radiation therapy
- small molecule
- mass spectrometry
- type diabetes
- bone marrow
- insulin resistance
- binding protein
- radiation induced
- amino acid
- cell therapy