Sustained, Controlled and Stimuli-Responsive Drug Release Systems Based on Nanoporous Anodic Alumina with Layer-by-Layer Polyelectrolyte.
Maria Porta-I-BatallaChris EcksteinElisabet Xifré-PérezPilar FormentínJ Ferré-BorrullLluis F MarsalPublished in: Nanoscale research letters (2016)
Controlled drug delivery systems are an encouraging solution to some drug disadvantages such as reduced solubility, deprived biodistribution, tissue damage, fast breakdown of the drug, cytotoxicity, or side effects. Self-ordered nanoporous anodic alumina is an auspicious material for drug delivery due to its biocompatibility, stability, and controllable pore geometry. Its use in drug delivery applications has been explored in several fields, including therapeutic devices for bone and dental tissue engineering, coronary stent implants, and carriers for transplanted cells. In this work, we have created and analyzed a stimuli-responsive drug delivery system based on layer-by-layer pH-responsive polyelectrolyte and nanoporous anodic alumina. The results demonstrate that it is possible to control the drug release using a polyelectrolyte multilayer coating that will act as a gate.
Keyphrases
- drug release
- drug delivery
- cancer therapy
- tissue engineering
- induced apoptosis
- coronary artery
- metal organic framework
- coronary artery disease
- bone mineral density
- heart failure
- cell cycle arrest
- signaling pathway
- computed tomography
- soft tissue
- cell death
- body composition
- pet imaging
- left ventricular
- adverse drug
- aortic stenosis
- pi k akt
- oral health
- aortic valve
- iron oxide nanoparticles