Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin secretion.

Rita S Patarrão Nádia Duarte Inês Coelho Joey Ward Rogério T Ribeiro Maria João Meneses Rita Andrade João Costa Isabel Correia José Manuel Boavida Rui Duarte Luís Gardete-Correia José Luís Medina Jill P Pell John R Petrie Joao Filipe Raposo Maria Paula Macedo Carlos P Gonçalves

Published in: Diabetologia (2022)

These results showed the DPP4 gene as a strong determinant of post-OGTT levels via glucose-sensing mechanisms that are abrogated in prediabetes. We propose that impairments in DPP4 control of post-OGTT insulin responses are part of molecular mechanisms underlying early metabolic disturbances associated with type 2 diabetes.

Keyphrases

genome wide
blood glucose
copy number
type diabetes
glycemic control
gene expression
single molecule
adipose tissue
insulin resistance
transcription factor