Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides.

Snehlata YadavBalasubramanian NarasimhanSiong M LimKalavathy RamasamyMani VasudevanSyed Adnan Ali ShahManikandan Selvaraj

Published in: Chemistry Central journal (2017)

The molecular docking studies of potent anticancer compounds 5l, 5k, 5i and 5p showed their putative binding mode and significant interactions with cyclin-dependent kinase-8 as prospective agents for treating colon cancer.

Keyphrases

molecular docking
molecular dynamics simulations
case control
cell cycle
anti inflammatory
protein kinase
signaling pathway