Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression.
Hashni Epa Vidana GamageSayyed Hamed ShahoeiSamuel T AlbrightYu WangAmanda J SmithRachel FarmerEmma C FinkElise JacquinErin WeisserRafael O BautistaMadeline A HennClaire P SchaneAdam T NelczykLiqian MaAnasuya Das GuptaShruti V BendreTiffany NguyenSrishti TiwariNatalia KrawczynskaSisi HeEvelyn TjoandaHong ChenMaria SverdlovPeter H GannRomain BoidotFrederique VegranSean W FanningLionel ApetohPaul J HergenrotherErik Russell NelsonPublished in: bioRxiv : the preprint server for biology (2023)
expansion and subsequent tumor growth/metastasis. Activation of NR0B2 with small molecule agonists, including one developed herein, attenuates tumor growth and metastasis in murine models of mammary cancer.