Pathophysiological Link Between Chronic Rhinosinusitis and Ear Disease.
Christian Calvo-HenríquezEugenio Di CorsoIsam AlobidElena CantoneTiziana Di CesareJoaquim MullolPublished in: Current allergy and asthma reports (2023)
Available evidence suggests a higher prevalence of otologic symptoms in patients suffering from CRS, affecting up to 87% of patients. These symptoms may be related to Eustachian tube dysfunction, which improves after treatment for CRS. A few studies suggested a potential but not confirmed role of CRS in cholesteatoma, chronic otitis media, and sensorineural hypoacusis. A special type of otitis media with effusion (OME) may occur in patients with CRS, which seems to respond well to new biologic therapy. Ear symptoms appear to be highly prevalent in patients with CRS. So far, the available evidence is robust only for Eustachian tube dysfunction, which has been shown to be particularly impaired in CRS patients. Additionally, the Eustachian tube function appears to improve after treatment for CRS. Finally, interesting preliminary data were described for eosinophilic otitis media, as it appears to respond well to the treatment with biologics.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- rheumatoid arthritis
- prognostic factors
- stem cells
- mesenchymal stem cells
- machine learning
- physical activity
- chronic rhinosinusitis
- bone marrow
- depressive symptoms
- sleep quality
- hearing loss
- artificial intelligence
- cell therapy
- replacement therapy