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Uncovering the prognostic gene signatures for the improvement of risk stratification in cancers by using deep learning algorithm coupled with wavelet transform.

Yiru ZhaoYifan ZhouYuan LiuYinyi HaoMenglong LiXuemei PuChuan LiZhining Wen
Published in: BMC bioinformatics (2020)
Our results indicated that gene expression-based SWT-CNN model can be an excellent tool for stratifying the prognostic risk for cancer patients. In addition, the representative features of SWT-CNN were validated to be useful for evaluating the importance of the genes in the risk stratification and can be further used to identify the prognostic gene signatures.
Keyphrases
  • genome wide
  • deep learning
  • convolutional neural network
  • gene expression
  • dna methylation
  • genome wide identification
  • copy number
  • machine learning
  • genome wide analysis
  • transcription factor