Celecoxib treatment dampens LPS-induced periapical bone resorption in a mouse model.

Igor Bassi Ferreira PeteanL A Almeida-JuniorM F M ArnezA M QueirozR A B SilvaL A B SilvaL H FaccioliFrancisco Wanderley Garcia de Paula E Silva

Published in: International endodontic journal (2021)

The selective COX-2 inhibitor celecoxib reduced osteoclastogenic signalling and activity that dampened bone resorption in LPS-induced apical periodontitis in mice, with greater efficacy than the nonselective inhibitor indomethacin.

Keyphrases

lps induced
inflammatory response
bone loss
mouse model
bone mineral density
soft tissue
bone regeneration
high fat diet induced
postmenopausal women
type diabetes
combination therapy