Differentiating idiopathic inflammatory myopathies by automated morphometric analysis of MHC-1, MHC-2 and ICAM-1 in muscle tissue.

Anna NishimuraChristopher NelkeMelanie HuberAlexander MenschAngela RothChristoph OberwittlerBjörn ZimmerleinHeidrun H KrämerEva Neuen-JacobWerner StenzelUlf Müller-LadnerTobias RuckAnne Schänzer

Published in: Neuropathology and applied neurobiology (2024)

Automated morphometric analysis provides precise quantitative data on immune-associated proteins that can be integrated into our pathophysiological understanding of IIM. Further, ICAM-1 holds diagnostic value for the detection of IIM pathology.

Keyphrases

deep learning
machine learning
high throughput
skeletal muscle
oxidative stress
electronic health record
big data
high resolution
loop mediated isothermal amplification
label free
artificial intelligence
contrast enhanced
mass spectrometry