A Novel Vitamin D Receptor Agonist, VS-105, Improves Bone Mineral Density without Affecting Serum Calcium in a Postmenopausal Osteoporosis Rat Model.

J Ruth Wu-WongJerry L WessaleYung-Wu ChenTheresa ChenMaysaa OubaidinPhimon Atsawasuwan

Published in: Journal of exploratory research in pharmacology (2020)

VS-105 is efficacious in improving BMD in a dose range that does not affect serum Ca in OVX rats; the improvement in BMD by VS-105 is attributable to increased osteoblastic activity and reduced osteoclastic bone resorption.

Keyphrases

bone mineral density
postmenopausal women
body composition
protein kinase