CYP2C19*2 genetic polymorphism and incidence of in-stent restenosis in patients on clopidogrel: a matched case-control study.
Sara OsamaFrancesca WirthGraziella ZahraChristopher BarbaraRobert G XuerebLiberato CamilleriLilian M AzzopardiPublished in: Drug metabolism and personalized therapy (2021)
The proportion of patients who were carriers of one or two CYP2C19*2 alleles who presented with DES-ISR within one-year post-PCI while on clopidogrel was significantly higher compared to patients with no documented ISR.
Keyphrases
- acute coronary syndrome
- percutaneous coronary intervention
- antiplatelet therapy
- end stage renal disease
- ejection fraction
- chronic kidney disease
- coronary artery disease
- acute myocardial infarction
- st segment elevation myocardial infarction
- prognostic factors
- atrial fibrillation
- genome wide
- dna methylation
- heart failure
- patient reported outcomes
- gene expression
- coronary artery bypass grafting
- copy number