Development and validation of an analytical method for trace-level quantification of genotoxic nitrosamine impurities in losartan and hydrochlorothiazide fixed-dose combination tablets using ultra performance liquid chromatography triple quadrupole mass spectrometry.
Ravi PatelSanjay PurohitRavisinh SolankiDignesh KhuntChhaganbhai PatelRucha PatelShalin ParikhPublished in: Rapid communications in mass spectrometry : RCM (2023)
The developed method can be incorporated into an official monograph and applied for routine quality control analysis of losartan and HCTZ fixed-dose combination tablets.
Keyphrases
- liquid chromatography
- mass spectrometry
- quality control
- high resolution mass spectrometry
- tandem mass spectrometry
- high resolution
- simultaneous determination
- high performance liquid chromatography
- angiotensin ii
- gas chromatography
- solid phase extraction
- capillary electrophoresis
- clinical practice
- heavy metals
- risk assessment