Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy.
Jonas BochemHenning ZelbaJanine SpreuerTeresa AmaralNikolaus B WagnerAndrea GaisslerOltin T PopKarolin ThielCan YurttasDaniel SoffelStephan ForchhammerTobias SinnbergHeike NiessnerFriedegund MeierPatrick TerheydenAlfred KönigsrainerClaus GarbeLukas FlatzGraham P PawelecThomas K EigentlerMarkus W LöfflerBenjamin WeideKilian Wistuba-HamprechtPublished in: Journal for immunotherapy of cancer (2022)
Our findings suggest a PD-1 blockade-dependent infiltration of melanoma-reactive T cells from the periphery into the tumor and imply that this seminally contributes to effective treatment.