Comparative analysis of the tumor immune-microenvironment of primary and brain metastases of non-small-cell lung cancer reveals organ-specific and EGFR mutation-dependent unique immune landscape.

Seung Geun SongSehui KimJaemoon KohJeemin YimBogyeong HanYoung A KimYoon Kyung JeonDoo Hyun Chung

Published in: Cancer immunology, immunotherapy : CII (2021)

Our findings illustrate the immune landscape of brain metastases from NSCLC and reveal potential therapeutic strategies targeting cellular and non-cellular components of the tumor immune-microenvironment.

Keyphrases

brain metastases
small cell lung cancer
stem cells
single cell
gene expression
epidermal growth factor receptor
genome wide
tyrosine kinase
climate change
dna methylation
human health