Frontal lobe metabolic alterations characterizing Parkinson's disease cognitive impairment.

Shefali ChaudharyS Senthil KumaranVinay GoyalM KalaivaniGauri Shanker KaloiyaRajesh SagarNalin MehtaAchal Kumar SrivastavaN R Jagannathan

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)

The frontal metabolic profile is altered in cognitively impaired PD compared with cognitively normal PD. Neuronal function loss (NAA), altered energy metabolism (Cr), and cholinergic (Cho) neural transmission are implicated in PD cognitive pathology. Frontal neuro-metabolism may promisingly serve as PD cognitive biomarker.

Keyphrases

cognitive impairment
working memory
functional connectivity
cognitive decline
mild cognitive impairment
subarachnoid hemorrhage
cerebral ischemia