Proteomics research of SARS-CoV-2 and COVID-19 disease.
Nan ZhangSiyuan WangCatherine C L WongPublished in: Medical review (Berlin, Germany) (2022)
Currently, coronavirus disease 2019 (COVID-19) is still spreading in a global scale, exerting a massive health and socioeconomic crisis. Deep insights into the molecular functions of the viral proteins and the pathogenesis of this infectious disease are urgently needed. In this review, we comprehensively describe the proteome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and summarize their protein interaction map with host cells. In the protein interaction network between the virus and the host, a total of 787 host prey proteins that appeared in at least two studies or were verified by co-immunoprecipitation experiments. Together with 29 viral proteins, a network of 1762 proximal interactions were observed. We also review the proteomics results of COVID-19 patients and proved that SARS-CoV-2 hijacked the host's translation system, post-translation modification system, and energy supply system via viral proteins, resulting in various immune disorders, multiple cardiomyopathies, and cholesterol metabolism diseases.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- public health
- infectious diseases
- mass spectrometry
- healthcare
- protein protein
- amino acid
- induced apoptosis
- risk assessment
- cell cycle arrest
- climate change
- single molecule
- cell death
- cell proliferation
- social media
- network analysis
- case control
- human health
- pi k akt