Ag/Au Bimetallic Nanoparticles Inhibit Tumor Growth and Prevent Metastasis in a Mouse Model.

Hector Katifelis Iuliia Mukha Penelope BouziotisNadiia VityukCharalampos TsoukalasAndreas C LazarisAnna LyberopoulouGeorge E TheodoropoulosEfstathios P EfstathopoulosMaria Gazouli

Published in: International journal of nanomedicine (2020)

Based on our results, Ag3Au1Trp1:2NPs express anti-tumor and anti-metastatic effects in vivo. Ag3Au1Trp1:2NPs also reach tumor site via the enhancement and retention effect which results in the apoptotic death of cancerous cells selectively via the extrinsic TRAIL-dependent pathway.

Keyphrases

visible light
sensitive detection
quantum dots
mouse model
reduced graphene oxide
induced apoptosis
highly efficient
cell death
cell cycle arrest
small cell lung cancer
squamous cell carcinoma
endoplasmic reticulum stress
oxide nanoparticles
gold nanoparticles
oxidative stress
cell proliferation
pi k akt