Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia.
Suqi DengJuan DuRobert Peter GaleLu WangHuien ZhanFangshu LiuKexiu HuangHao XuHui ZengPublished in: Leukemia (2023)
Acute myeloid leukaemia (AML) cells metabolise glucose by glycolysis-based re-programming. However, how glucose uptake is partitioned between leukaemia cells and other cells of the bone marrow micro-environment is unstudied. We used a positron emission tomography (PET) tracer 18 F fluorodeoxyglucose ([ 18 F]-FDG) probe and transcriptomic analyses to detect glucose uptake by diverse cells in the bone marrow micro-environment in a MLL-AF9-induced mouse model. Leukaemia cells had the greatest glucose uptake with leukaemia stem and progenitor cells having the greatest glucose uptake. We also show the effects of anti-leukaemia drugs on leukaemia cell numbers and glucose uptake. Our data suggest targeting glucose uptake as a potential therapy strategy in AML if our observations are validated in humans with AML.
Keyphrases
- bone marrow
- positron emission tomography
- induced apoptosis
- blood glucose
- computed tomography
- acute myeloid leukemia
- mesenchymal stem cells
- pet ct
- mouse model
- endoplasmic reticulum stress
- pet imaging
- signaling pathway
- type diabetes
- oxidative stress
- dendritic cells
- machine learning
- liver failure
- metabolic syndrome
- small molecule
- blood pressure
- risk assessment
- immune response
- stem cells
- intensive care unit
- drug delivery
- electronic health record
- deep learning
- glycemic control