Assessing the Role of Long Noncoding RNA in Nucleus Accumbens in Subjects With Alcohol Dependence.

John DrakeGowon O McMichaelEric Sean VornholtKellen CresswellVernell WilliamsonChris ChatzinakosMohammed MamdaniSiddharth HariharanKenneth S KendlerGursharan KalsiBrien P RileyMikhail DozmorovMichael F MilesSilviu-Alin BacanuVladimir I Vladimirov

Published in: Alcoholism, clinical and experimental research (2020)

Our study identified lncRNA and gene networks significantly associated with AD in the NAc, coordinated lncRNA and mRNA coexpression changes, highlighting potentially regulatory functions for the lncRNA, and our genetic (cis-eQTL) analysis provides novel insights into the etiological mechanisms of AD.

Keyphrases

long noncoding rna
transcription factor
genome wide
copy number
long non coding rna
gene expression
binding protein
alcohol consumption
genome wide identification