Conditional deletion of IκBζ in hematopoietic cells promotes functional recovery after spinal cord injury in mice.

Naoya TakiAtsushi KimuraYasuyuki ShiraishiTakashi MaruyamaTsukasa OhmoriKatsushi Takeshita

Published in: Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (2024)

IκBζ deletion in hematopoietic cells improved functional recovery after SCI, possibly by shifting the inflammatory balance towards anti-inflammatory and pro-regenerative directions.

Keyphrases

induced apoptosis
anti inflammatory
cell cycle arrest
stem cells
bone marrow
oxidative stress
mesenchymal stem cells
spinal cord injury
endoplasmic reticulum stress
cell death
type diabetes
cell proliferation
insulin resistance
pi k akt
wild type