Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart.
Kylene M HaroldSatoshi MatsuzakiAtul PranayBrooke L LovelandAlbert BatushanskyMaria F NewhardtCraig EysterStavros StavrakisYing Ann ChiaoMichael KinterKenneth M HumphriesPublished in: Journal of the American Heart Association (2024)
Loss of PFKFB2 results in metabolic remodeling marked by cardiac ancillary pathway activation. This could delineate an underpinning of pathologic changes to mechanical and electrical function in the heart.