Oral cytarabine ocfosfate pharmacokinetics and assessment of leukocyte biomarkers in normal dogs.

Danielle M ZwuesteKaren M VernauWilliam VernauBruno H PypendopHeather K KnychCarlos A RodriguesAmir KolMaria QuestaPeter J Dickinson

Published in: Journal of veterinary internal medicine (2023)

Oral CO may produce prolonged serum Ara-C half-lives at concentrations sufficient to induce functional changes in peripheral leukocytes and is associated with prolonged retention of DNA-incorporated Ara-CTP. Application of functional and active metabolite assessment is feasible and may provide more relevant data to determine optimal dosing regimens for Ara-C-based treatments.

Keyphrases

peripheral blood
acute myeloid leukemia
high dose
electronic health record
single molecule
low dose
data analysis