Characterization, in vitro dissolution, and pharmacokinetics of different batches of efavirenz raw materials.

Danilo César Galindo BedorNoely Camila Tavares Cavalcanti BedorJoão Gomes Pontes NetoLucas José de Alencar DandaFlávio Martins de OliveiraGuilherme Henrique Onório de OliveiraJosé Lamartine Soares SobrinhoEric BeyssacWhocely Victor de CastroDavi Pereira de Santana

Published in: Drug development and industrial pharmacy (2021)

The FaSSIF medium discriminated the dissolution profiles of EFV APIs. Small differences in particle size distribution had a significant impact on the biopharmaceutical parameters of EFV, suggesting that strict control of such parameter is an important aspect during API development and drug formulation.

Keyphrases

drug delivery
hiv infected
antiretroviral therapy
adverse drug
drug induced