SPICY: a method for single scan rotating frame relaxometry.

T 1 ρ is an NMR relaxation mode that is sensitive to low frequency molecular motions, making it an especially valuable tool in biomolecular research. Here, we introduce a new method, SPICY, for measuring T 1 ρ relaxation times. In contrast to conventional T 1 ρ experiments, in which the sequence is repeated many times to determine the T 1 ρ time, the SPICY sequence allows determination of T 1 ρ within a single scan, shortening the experiment time remarkably. We demonstrate the method using 1 H T 1 ρ relaxation dispersion experiments. Additionally, we combine the sequence with spatial encoding to produce 1D images in a single scan. We show that T 1 ρ relaxation times obtained using the single scan approach are in good agreement with those obtained using the traditional experiments.