Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage.
Yucong PengJianfeng ZhuangGuangyu YingHanhai ZengHang ZhouYang CaoHuaijun ChenChaoran XuXiongjie FuHangzhe XuJianru LiShenglong CaoJingyin ChenChi GuFeng YanChen GaoPublished in: Journal of neuroinflammation (2020)
Microglial STING yielded neuroinflammation after SAH, while pharmacologic inhibition of STING could attenuate SAH-induced inflammatory injury at least partly by activating AMPK signal. These data supported the notion that STING might be a potential therapeutic target for SAH.
Keyphrases
- subarachnoid hemorrhage
- cerebral ischemia
- brain injury
- lipopolysaccharide induced
- skeletal muscle
- lps induced
- inflammatory response
- high glucose
- signaling pathway
- diabetic rats
- immune response
- traumatic brain injury
- oxidative stress
- protein kinase
- dendritic cells
- big data
- electronic health record
- neuropathic pain
- cognitive impairment
- drug induced
- blood brain barrier
- machine learning
- spinal cord injury
- risk assessment
- endothelial cells
- spinal cord
- genome wide identification