Cell demise inhibited: Unexpected liaisons between mitochondria and IκΒα.
Evangelos PazarentzosPublished in: Molecular & cellular oncology (2022)
IκΒα (the protein product of NFKBIA gene) has widely been considered a pro- apoptotic factor due to its ability to inhibit the anti-apoptotic transcription factor NFκB. Our findings indicate that IκΒα also exerts a strong anti-apoptotic activity at the outer mitochondria membrane (OMM). This function we uncovered is distinct from its ability to sequester and inhibit NFκB. IκΒα instead binds to voltage dependent anion channel 1 (VDAC1) and Hexokinase 2 (HK2), stabilizes this complex and prevents mitochondria outer membrane permeabilisation (MOMP) and apoptosis.
Keyphrases
- cell death
- cell cycle arrest
- signaling pathway
- transcription factor
- lps induced
- oxidative stress
- pi k akt
- anti inflammatory
- nuclear factor
- single cell
- genome wide identification
- cell therapy
- genome wide
- copy number
- protein protein
- inflammatory response
- endoplasmic reticulum stress
- cell proliferation
- stem cells
- mesenchymal stem cells
- immune response
- dna binding
- small molecule
- high glucose