Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive myeloid sarcoma and acute B-lymphoblastic leukemia.
Giuliana RizzutoMatteo LeoncinSilvia ImbergamoDaniela TaurinoMaria Caterina MicoManuela TosiAnna MichelatoKsenija BuklijasOrietta SpinelliFederico LussanaFederica LessiMarco PizziLaura BonaldiGianni BinottoAlessandro RambaldiCarmela GurrieriPublished in: Clinical case reports (2022)
The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1 - JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1 - JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.