[The relationship between inflammation, cognitive disorders and neuroimaging data in schizophrenia].

Vadim Ushakov I K Malashenkova G P Kostyuk Marat Kurmishev S A Krinsky S I Kartashov D P Ogurtsov L V Bravve M A Kaydan N A Hailov E I Chekulaeva N A Didkovsky

Published in: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2020)

Levels of markers of systemic inflammation and growth factor VEGF-A as well as the activation of humoral immunity are increased in patients with schizophrenia compared with controls. For the first time, the relationship of immunological parameters with the coefficient of quantitative anisotropy in the area of the corpus callosum in schizophrenia was revealed. The results indicate the possible value of indicators of the activation of the humoral immune response and systemic inflammation as markers of neurophysiological changes and cognitive dysfunction in schizophrenia.

Keyphrases

immune response
growth factor
bipolar disorder
oxidative stress
dendritic cells
toll like receptor
endothelial cells
electronic health record
high resolution
magnetic resonance imaging
single cell
computed tomography