Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia.
Ming-Yii HuangChia-En TuShu-Chi WangYung-Li HungChia-Cheng SuShih-Hua FangChi-Shuo ChenPo-Len LiuWei-Chung ChengYu-Wei HuangChia-Yang LiPublished in: BMC complementary and alternative medicine (2018)
Our results indicate the anti-inflammatory effects of corylin acted through attenuating LPS-induced inflammation and inhibiting the activation of NLRP3 inflammasome in LPS-activated BV2 cells. These results suggest that corylin might have potential in treating brain inflammation and attenuating the progression of neurodegeneration diseases.
Keyphrases
- lps induced
- nlrp inflammasome
- inflammatory response
- lipopolysaccharide induced
- oxidative stress
- anti inflammatory
- toll like receptor
- induced apoptosis
- cell cycle arrest
- signaling pathway
- white matter
- resting state
- human health
- multiple sclerosis
- functional connectivity
- risk assessment
- cell proliferation
- blood brain barrier
- spinal cord
- brain injury