A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease.

Yuyang WangTongtong LiuFang MaXiaoguang LuHuimin MaoWeie ZhouLiping YangPing Li Yongli Zhan

Published in: Journal of diabetes research (2020)

Kaempferol and VEGFA were represented as the uppermost active ingredient and core gene of TwHF in treating DKD, respectively. The key mechanisms of TwHF against DKD might be involved in the reduction of renal inflammation by downregulating VEGFA.

Keyphrases

oxidative stress
type diabetes
genome wide
copy number
wound healing
gene expression
transcription factor