GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.

Alexandre J C LoucifPierre-Philippe SaintotJia LiuBrett M AntonioShannon G ZellmerKatrina YogerEmma L VealeAnna WilbreyKiyoyuki OmotoLishuang CaoAlex GutteridgeNeil A CastleEdward B StevensAlistair A Mathie

Published in: British journal of pharmacology (2017)

This article is part of a themed section on Recent Advances in Targeting Ion Channels to Treat Chronic Pain. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.12/issuetoc.

Keyphrases

chronic pain
neuropathic pain
spinal cord
pain management
oxidative stress
benign prostatic hyperplasia
cancer therapy
lower urinary tract symptoms
transcranial direct current stimulation
spinal cord injury
drug delivery
working memory