GSTM1 Deletion Exaggerates Kidney Injury in Experimental Mouse Models and Confers the Protective Effect of Cruciferous Vegetables in Mice and Humans.

Joseph C GigliottiAdrienne TinShirin PourafsharSylvia CechovaYves T WangSun-Sang J SungGabor Bodonyi-KovacsJanet V CrossGuang YangNhu NguyenFang ChanCasey RebholzBing YuMegan L GroveMorgan E GramsAnna KottgenRobert ScharpfPhillip RuizEric BoerwinkleJosef Coresh Thu H Le

Published in: Journal of the American Society of Nephrology : JASN (2019)

Our data support a role for the GSTM1 enzyme in the modulation of oxidative stress, inflammation, and protective metabolites in CKD.

Keyphrases

oxidative stress
mouse model
chronic kidney disease
dna damage
ischemia reperfusion injury
electronic health record
ms ms
diabetic rats
induced apoptosis
high fat diet induced
big data
type diabetes
health risk
health risk assessment
metabolic syndrome
heavy metals
risk assessment
wild type