Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review.
Saad AlhumaidKoblan M Al MutaredZainab Al AlawiZainah SabrOla AlkharsMuneera AlabdulqaderNourah Al DossaryFatemah M ALShakhsRabab Abbas MajzoubYousef Hassan AlalawiKhalid Al NoaimAbdulrahman A AlnaimMohammed A Al GhamdiAbdulaziz A AlahmariSawsan Sami AlbattatYasin S AlmubarakEssam Mohammed Al AbdulmohsenHanan Al ShaikhMortadah Essa AlobaidanHadi Hassan AlmusallamFatimah Mohammed AlhassanMohammed Abdulhadi AlamerJawad Ali Al-HajjiDuaa Ali Al-HajjiAnwar Ahmed AlkadiAbbas Al MutairAli A RabaanPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2023)
Children with IEIs infected with SARS-CoV-2 may experience higher rates of ICU admission and mortality in comparison with the immunocompetent pediatric populations. Underlying immune defects does seem to be independent risk factors for severe SARS-CoV-2 infection in children with IEIs, a number of children with SCID and CID were reported to have prolonged infections-though the number of patients is small-but especially immune dysregulation diseases (XLP1 and XLP2) and innate immunodeficiencies impairing type I interferon signalling (IFNAR1, IFNAR2 and TBK1).