Association of MRI leptomeningeal enhancement with disability worsening in progressive multiple sclerosis: A clinical and post-mortem study.
Marco VercellinoGianfranco CostantiniMaurizio CogoniLaura LequioPaola SciortinoFederica De NegriStella MarasciuloConsuelo ValentiniChiara BosaPaola GarelliAnna RolandoAndrea CalvoGiovanni MoranaPaola CavallaPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2023)
LME is frequently detected in pMS patients using 1.5T MRI and is independently predictive of disability progression. LME could result from both focal leptomeningeal post-inflammatory fibrosis and inflammation.
Keyphrases
- multiple sclerosis
- end stage renal disease
- oxidative stress
- magnetic resonance imaging
- contrast enhanced
- ejection fraction
- white matter
- chronic kidney disease
- cerebrospinal fluid
- diffusion weighted imaging
- prognostic factors
- peritoneal dialysis
- computed tomography
- magnetic resonance
- small cell lung cancer
- patient reported outcomes