Recent advances in understanding the role of FOXO3.
Renae J StefanettiSarah VoisinAaron RussellSéverine LamonPublished in: F1000Research (2018)
The forkhead box O3 (FOXO3, or FKHRL1) protein is a member of the FOXO subclass of transcription factors. FOXO proteins were originally identified as regulators of insulin-related genes; however, they are now established regulators of genes involved in vital biological processes, including substrate metabolism, protein turnover, cell survival, and cell death. FOXO3 is one of the rare genes that have been consistently linked to longevity in in vivo models. This review provides an update of the most recent research pertaining to the role of FOXO3 in (i) the regulation of protein turnover in skeletal muscle, the largest protein pool of the body, and (ii) the genetic basis of longevity. Finally, it examines (iii) the role of microRNAs in the regulation of FOXO3 and its impact on the regulation of the cell cycle.
Keyphrases
- transcription factor
- cell cycle
- pi k akt
- dna binding
- cell death
- signaling pathway
- genome wide identification
- skeletal muscle
- protein protein
- amino acid
- binding protein
- type diabetes
- cell proliferation
- bone mineral density
- small molecule
- adipose tissue
- insulin resistance
- gene expression
- metabolic syndrome
- cell cycle arrest
- glycemic control