The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders.
Sonia MissiroliIlaria GenoveseMariasole PerroneBianca VezzaniVeronica A M VittoCarlotta GiorgiPublished in: Journal of clinical medicine (2020)
The main features that are commonly attributed to mitochondria consist of the regulation of cell proliferation, ATP generation, cell death and metabolism. However, recent scientific advances reveal that the intrinsic dynamicity of the mitochondrial compartment also plays a central role in proinflammatory signaling, identifying these organelles as a central platform for the control of innate immunity and the inflammatory response. Thus, mitochondrial dysfunctions have been related to severe chronic inflammatory disorders. Strategies aimed at reestablishing normal mitochondrial physiology could represent both preventive and therapeutic interventions for various pathologies related to exacerbated inflammation. Here, we explore the current understanding of the intricate interplay between mitochondria and the innate immune response in specific inflammatory diseases, such as neurological disorders and cancer.
Keyphrases
- oxidative stress
- cell death
- immune response
- inflammatory response
- papillary thyroid
- cell proliferation
- squamous cell
- reactive oxygen species
- endoplasmic reticulum
- physical activity
- cell cycle arrest
- childhood cancer
- early onset
- toll like receptor
- squamous cell carcinoma
- high throughput
- cell cycle
- brain injury
- single cell
- signaling pathway
- subarachnoid hemorrhage