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Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever.

Hannah R WardillC E M de MooijA R da Silva FerreiraI P van de PeppelR HavingaH J M HarmsenW J E TissingN M A Blijlevens
Published in: Cancer chemotherapy and pharmacology (2021)
We developed a novel translational model of melphalan-induced toxicity, which has excellent homology with the well-known clinical features of HDM transplantation. Application of this model will accelerate fundamental and translational study of melphalan-induced toxicity, with the clinical parallels of this model ensuring a greater likelihood of clinical success.
Keyphrases
  • high dose
  • high glucose
  • diabetic rats
  • oxidative stress
  • drug induced
  • stem cells
  • endothelial cells
  • low dose