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How do nuclear factor kappa B (NF-κB)1 and NF-κB2 defects lead to the incidence of clinical and immunological manifestations of inborn errors of immunity?

Nazanin FathiHanieh MojtahediMarzieh NasiriHassan AbolhassaniMahsa Yousefpour MarzbaliMarzieh EsmailiFereshteh SalamiFurozan BiglariNima Rezaei
Published in: Expert review of clinical immunology (2023)
The present review article has explained the mechanism of contributions of the NF-κB1 and NF-κB2 deficiency in revealing immunodeficiency symptoms, specifically immunological and clinical manifestations. These mechanisms demonstrate the importance of NF-κB1 and NF-κB2 signaling pathways for B and T cell development, activation, antibody production, and immunotolerance. Although, the manifestation of a mutation can range from no symptoms to severe complications in a family.
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