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Quality-adjusted time without symptoms of disease or toxicity and quality-adjusted progression-free survival with niraparib maintenance in first-line ovarian cancer in the PRIMA trial.

Maria-Pilar Barretina-GinestaBradley J MonkSileny HanBhavana PothuriAnnika AuranenDana M ChaseDomenica LorussoCharles AndersonSophie Abadie-LacourtoisieNoelle ClovenElena I BraicuAmnon AmitAndrés RedondoRuchit ShahNehemiah KebedeCarol HawkesDivya GuptaTatia WoodwardDavid M O'MalleyAntonio Gonzáles Martin
Published in: Therapeutic advances in medical oncology (2022)
These results show that the survival benefits of niraparib treatment remain when accounting for patients' quality of life. These benefits were seen not only in HRd patients who are known to respond better to niraparib, but in the overall group of patients who took niraparib.
Keyphrases
  • end stage renal disease
  • free survival
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • peritoneal dialysis
  • prognostic factors
  • physical activity
  • study protocol