Investigating drug safety in pregnancy based on the German Pharmacoepidemiological Research Database (GePaRD): A proof-of-concept analysis on the association between valproate and spina bifida.

Ulrike Haug Bianca Kollhorst Cristina RebordosaKathrin ThöneKatarina DatheChristof SchaeferMarlies Onken

Published in: Pharmacoepidemiology and drug safety (2022)

Our proof-of-concept analysis based on GePaRD showed a strong association between intrauterine exposure to VPA and occurrence of spina bifida. The results are plausible and consistent with the literature, supporting the suitability of GePaRD and the developed algorithms to conduct studies on drug safety in pregnancy.

Keyphrases

machine learning
systematic review
preterm birth
adverse drug
emergency department
drug induced
case control