Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy.

Jamie M WalkerMiranda E OrrTimothy C OrrEmma L ThornThomas D ChristieRaquel T YokodaMeenakshi VijAlexander J EhrenbergGabriel A MarxAndrew T McKenzieJustin KauffmanEnna SelmanovicThomas WisniewskiEleanor DrummondCharles L WhiteJohn F CraryKurt FarrellTiffany F KautzElena V DaoudTimothy Eric Richardson

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)

Synaptic health is inversely correlated with local p-tau burden. The proteome of NFT- and non-NFT-bearing neurons is influenced by the presence of Aβ in the hippocampus. Neurons in possible PART cases share more proteomic similarities with neurons in ADNC than they do with neurons in definite PART cases.

Keyphrases

spinal cord
healthcare
public health
mental health
mass spectrometry
spinal cord injury
cerebral ischemia
label free
risk factors
risk assessment
cerebrospinal fluid
prefrontal cortex
social media
human health