Ashkenazi Jewish and Other White APC I1307K Carriers Are at Higher Risk for Multiple Cancers.
Esther ForkoshMichael BergelKathryn E HatchellSarah M NielsenBrandie H LeachAriel A BensonEitan FriedmanEdward D EsplinLior H KatzPublished in: Cancers (2022)
This is the most extensive study to date conducted on I1307K carriers, although it is amenable to selection bias. NAW carrying I1307K had a higher risk of any cancer and several specific cancer types, whereas AJ carrying the variant had a risk for only a few select cancers. Our data add to the research base on I1307 carriers concerning future risk management.