Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.

Published in: Epilepsia (2018)

Diazepam elevates seizure threshold at steady-state plasma concentrations lower than previously recognized. The minimally effective plasma concentration provides a reference that may be considered when estimating the diazepam exposure required for acute seizure treatment.

Keyphrases

temporal lobe epilepsy
liver failure
respiratory failure
drug induced
solid phase extraction
mass spectrometry
hepatitis b virus
aortic dissection
simultaneous determination
tandem mass spectrometry