Medial prefrontal cortex to medial septum pathway activation improves cognitive flexibility in rats.
David M BortzCatalina M FeistritzerAnthony A GracePublished in: The international journal of neuropsychopharmacology (2023)
This study presents a top-down circuit from the prefrontal cortex to the midbrain, with the MS being a critical contributor, by which DA activity can be manipulated to promote flexible behavior.